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Results of our previous studies have suggested that enhanced generation of superoxide (O 2− ) may contribute to the pathophysiology of hypertension in Ren-2 transgenic rats (TGR). The present study was performed to evaluate in TGR the effects of chronic treatment with the O 2− scavenger tempol and the antioxidant apocynin on the development of hypertension. Systolic blood...
To examine the hypothesis that NAD(P)H ox idase (Nox)–derived superoxide generation is involved in the development of angiotensin II (ANG II)–induced hypertension, we evaluated the responses to ANG II infusion (65 ng/min; osmotic mini-pump) for 2 weeks in rats treated with or without apocynin (APO) (inhibitor of Nox subunits assembly) in drinking water (12 mmol/L). Rats were grouped according to their...
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