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Inhalation of adenosine-5′-monophosphate (AMP) causes bronchoconstriction in asthma but not in healthy subjects. Bronchoconstriction upon AMP inhalation is thought to occur by histamine release and subsequent binding to receptors on airway smooth muscle cells.To explain enhanced sensitivity to AMP in asthma, mast cell expression of the adenosine A 2A and A 2B receptors and histamine...
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