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Although synaptically released, vesicular Zn 2+ has been proposed to play a neuromodulatory or neuronal signaling role at the mossy fiber-CA3 synapse, Zn 2+ release remains controversial, especially when detected using fluorescent imaging. In the present study, we investigated synaptically released Zn 2+ at the mossy fiber (MF) synapse in rat hippocampal slices using three...
Investigations into the roles of Ca 2+ and Zn 2+ in cell biology have been facilitated by the development of sensitive fluorometric probes that have enabled the measurement of Ca 2+ or Zn 2+ in both extracellular and intracellular environments. It is critical to be aware of the specificity and relative selectivity of a probe for the targeted ion. Here, we investigated...
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