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The selective serotonin reuptake inhibitors (SSRIs) are the most widely prescribed pharmacological treatment for depression. Since their introduction many have considered the primary mechanism by which the SSRIs produced therapeutic improvement in depression is their effect on monoaminergic signalling. In recent years, however, the credibility of the monoamine theory and the therapeutic efficacy of...
Increasing evidence suggests that inflammation responses play an important role in the pathophysiology of depression. Clinically depressed patients manifest higher levels of inflammatory biomarkers, while proinflammatory cytokines induce neuropsychiatric symptoms (sickness behavior) as well as major depressive episode. Mechanisms that might be responsible for inflammation-mediated neuropsychiatric...
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