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Recent breakthroughs in neuroscience have led to the awareness that we should revise our traditional mode of thinking and studying the CNS, i.e. by isolating the privileged network of “intelligent” synaptic contacts. We may instead need to contemplate all the variegate communications occurring between the different neural cell types, and centrally involving the astrocytes. Basically, it appears that...
Progressive memory impairment, β-amyloid (Aβ) plaques associated with local inflammation, neurofibrillary tangles, and loss of neurons in selective brain areas are hallmarks of Alzheimer's disease (AD). Although β-amyloid precursor protein (APP) and Aβ have a central role in the etiology of AD, it is not clear which forms of APP or Aβ are responsible for the neuronal vulnerability in AD brain. Brain...
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