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Amyloid β-peptide (Aβ) has been shown to impair glucose uptake in cultured hippocampal neurons and shortens their survival time. Aβ appears to inhibit neuronal glucose uptake by activating Gs-coupled receptors and the cAMP-PKA system. In this study, Aβ inhibition of neuronal glucose uptake was studied by assaying translocation of glucose transporter isoform GLUT3, transcription of GLUT3 mRNA, and...
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