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Trials assessing the benefit of immediate androgen-deprivation therapy (ADT) for treating prostate cancer (PCa) have often done so based on differences in detectable prostate-specific antigen (PSA) relapse or metastatic disease rates at a specific time after randomization.Based on the long-term results of European Organization for Research and Treatment of Cancer (EORTC) trial 30891, we questioned...
EORTC trial 30891 compared immediate versus deferred androgen-deprivation therapy (ADT) in T0–4 N0–2 M0 prostate cancer (PCa). Many patients randomly assigned to deferred ADT did not require ADT because they died before becoming symptomatic. The question arises whether serum prostate-specific antigen (PSA) levels may be used to decide when to initiate ADT in PCa not suitable for local curative treatment...
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