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Purpose:To demonstrate that OKN007, a disulfonyl derivative of phenyl‐tert‐butyl nitrone (PBN), has anti‐glioma activity in the clinically relevant C6 rat glioma model using multi‐parametric magnetic resonance imaging.
Materials and Methods:Twenty‐one rats were intracerebrally implanted with C6 cells and administered OKN007 or kept as controls. Animals were monitored with MRI at 7 Tesla (T), using...
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