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Melatonin, secreted by the pineal gland, regulates the circadian rhythms and also plays an oncostatic role in cancer cells. Previously, we showed that melatonin induces the expression of Bim, a pro‐apoptotic Bcl‐2 protein, at both the transcriptional and post‐translational levels. In the present study, we investigated the molecular mechanisms underlying the melatonin‐mediated Bim upregulation through...
Melatonin (N‐acetyl‐5‐methoxytryptamine) has recently gained attention as an anticancer agent and for combined cancer therapy. In this study, we investigated the underlying molecular mechanisms of the effects of melatonin on cancer cell death. Treatment with melatonin induced apoptosis and upregulated the expression of the pro‐apoptotic protein Bcl‐2‐interacting mediator of cell death (Bim) in renal...
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