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We have reported previously that treatment of non‐obese diabetic (NOD) mice with the invariant natural killer T (iNK T) cell agonist α‐galactosylceramide C26:0 (α‐GalCer) or its T helper type 2 (Th2)‐biasing derivative α‐GalCer C20:2 (C20:2) protects against type 1 diabetes (T1D), with C20:2 yielding greater protection. After an initial response to α‐GalCer, iNK T cells become anergic upon restimulation...
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