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Anatomical pathology is a diagnostic specialty concerned with the diagnosis of disease based on the gross, microscopic and molecular characteristics of tissue. These characteristics are determined utilizing a variety of methods, including light microscopy, flow cytology, immunohistochemistry, special stains and other ancillary tests. These diagnostic modalities are utilized in each of the subspecialty...
Bladder pathology is one of the more challenging areas in the discipline of surgical pathology. The wide range of appearances of a normal bladder, the spectrum of diagnostic entities, and the limited availability of useful ancillary markers make the diagnosis of bladder cancer difficult in many instances. This chapter covers normal urothelium, benign and neoplastic surface lesions, and invasive bladder...
An autoimmune bullous disorder encompasses a heterogeneous group of disorders characterized by the presence of blisters and autoantibodies against structural components of the skin: desmosomal proteins, adhesion molecules of the dermal–epidermal junction, and epidermal/tissue transglutaminase. The most common autoimmune bullous diseases are bullous pemphigoid (BP) and pemphigus vulgaris (PV). Diagnosis...
Lynch syndrome (synonymous for HNPCC = hereditary non‐polyposis colorectal cancer) is characterized by the development of colorectal, endometrial, gastric, and various other cancers, and is caused by a mutation in one of the mismatch repair (MMR) genes. One of the main challenges in the clinical management of Lynch syndrome remains the broad spectrum and heterogeneity among and between affected families...
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