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Third-generation aromatase inhibitors (AIs) have proven to be superior to tamoxifen in terms of time to disease progression in patients with hormone receptor (HR) positive (HR+) status and, nowadays, are used in the adjuvant and neoadjuvant settings, and first-line therapy for advanced breast cancer. Letrozole is a third generation AI, as are anastrozole and exemestane. In the past, clinical studies...
Background:The predictive role of HER-2 in node-positive breastcancer patients receiving CMF or an anthracycline-based adjuvant therapyremains unclear. In addition, topo-isomerase II alpha (topo IIα), as thecellular target of anthracyclines, might have value as a predictivemarker. Patients and methods:Four hundred eighty-one archival primarytumor samples were collected among 777 patients entered...
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