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The nucleotides ATP, ADP, UTP and UDP acting on P2 receptors stimulate endothelium dependent dilatation mediated via nitric oxide, endothelium derived hyperpolarising factors, and prostacyclins (to a lesser extent). They are crucial for shear stress-mediated increases in blood flow and for the increase of tissue perfusion during exercise and hypoxia. The endothelium can also release potent contractile...
Anemia of chronic kidney disease (CKD) is common and is associated with diminished quality of life, cognitive impairment, cardiovascular morbidity, hospitalizations, and mortality. As the prevalence of end-stage renal disease continues to rise, the management of anemia represents a growing economic burden. Erythropoiesis-stimulating agents (ESA) are the mainstay of anemia management but their use...
Set the date range to filter the displayed results. You can set a starting date, ending date or both. You can enter the dates manually or choose them from the calendar.