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Intrahippocampal administration of the non-competitive N-methyl-d-aspartate (NMDA) receptor antagonist MK-801 (0.18 μg/side) significantly increased the number of errors in the working memory task with a three-panel runway setup. The increase in working memory errors by intrahippocampal MK-801 was significantly attenuated by concurrent infusion of D-cycloserine (1.0 μg/side) or spermidine (10 μg/side),...
Spermidine, an agonist of the polyamine site on the NMDA receptor/channel complex, did not affect the number of errors (attempts to pass through two incorrect panels of the three panel-gates at four choice points) in the working memory task with a three-panel runway setup, when injected bilaterally at 1 or 10 μg/side into the dorsal hippocampus. Intrahippocampal administration of the muscarinic receptor...
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