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Herein we review the role of apolipoprotein E (ApoE) in Alzheimer's disease (AD) and how ApoE interacts with various risk factors. ApoE is localized with the major pathological hallmarks of AD, extracellular amyloid deposits and intracellular neurofibrillary tangles. The ApoEε4 allele is associated with the development of late-onset familial and sporadic AD. ApoEε4 has a gene dose effect on the risk...
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