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Abstract. Release of bacterial endotoxin and cytokines induce cardiac failure during sepsis. We investigated the direct effects of E. coli endotoxin (lipopolysaccharide, LPS) and cytokines induced by LPS on the cardiac myocyte gene program. For in vivo-experiments adult Wistar rats were given 600g/day LPS i.v. for 24h or 7days. In addition, cultured adult rat cardiac myocytes were treated with LPS,...
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