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Osteomalazie ist bedingt durch verminderte Vitamin-D-Rezeptor- (VDR-) Wirkung und Kalziummangel mit gestörter Knochenmineralisierung. Ursachen sind mangelnde Sonnenexposition, niedrige Zufuhr von Kalzium und Vitamin D3, Malabsorption, reduzierte D-Hormonaktivierung bei Niereninsuffizienz, seltene Störungen des VDR-Signalweges und Phosphatverlustsyndrome. Leitsymptome sind Knochenschmerzen,...
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