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Being elderly is a risk factor for delayed wound healing. In aged skin, epidermal turnover is decreased by about 50%. This is accompanied by reductions in vascularization, granulation tissue, collagen, elastin, mast cells and fibroblasts. Age-related changes occur which impact all phases of healing. In general, the elderly have increased rates of infection and wound dehiscence, decreases in wound...
Neutrophil (PMN) recruitment from the blood stream into surrounding tissues involves a regulated series of events central to acute responses in host defense. Accumulation of PMN within mucosal tissues has historically been considered pathognomonic features of both acute and chronic inflammatory conditions. Historically, PMNs have been deemed necessary but detrimental when recruited, given the potential...
Nucleosides such as adenosine (Ado) influence nearly every aspect of physiology and pathophysiology. Extracellular nucleotides liberated at local sites of inflammation are metabolized through regulated phosphohydrolysis by a series of ecto-nucleotidases including ectonucleoside triphosphate diphosphohydrolase-1 (CD39) and ecto-5′-nucleotidase (CD73), found on the surface of a variety of cell types...
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