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The metabolic syndrome refers to the clustering of metabolic abnormalities more frequently than would be expected by chance alone. These metabolic abnormalities are all risk factors for cardiovascular disease (CVD), and the epidemiological association between these multiple risk factors points to the possibility of a unifying underlying pathophysiology. Obesity, in particular visceral adiposity, insulin...
References Plasma free fatty acids (FFAs) are elevated in obesity. By causing insulin resistance in all major insulin targets including muscle, liver, and endothelial cells, FFAs contribute to the development of type 2 diabetes (T2DM), hypertension, dyslipidemia, disorders of blood coagulation and fibrinolysis, and nonalcoholic fatty liver disease (NAFLD). In pancreatic β-cells, FFAs potentiate glucose-stimulated...
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