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Thrombophlebitis is a common complication of a widely used formulation of injectable diclofenac that employs propylene glycol and benzyl alcohol (PG–BA) as solvents. Initial studies of Dyloject ® , a novel injectable diclofenac solubilised with hydroxypropyl-β-cyclodextrin (HPβCD), suggested that this complication occurred less frequently and with lower severity with the newer formulation...
Thoracic epidural catheterization does not appear to be associated with more, or more serious, complications than lumbar epidural catheterization. Large prospective studies in patients undergoing abdominothoracic surgery did not reveal catheter-related permanent neurological injuries, the predicted maximum risk of which can be estimated to be of the order of 0.07%. Patients receiving epidural hydrophilic...
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