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Rationale. The investigation of rodent cocaine self-administration (SA) under conditions that promote escalating patterns of intake may provide insight into the loss of control over drug use that is central to human addiction. Objective. This study examines the effects of daily long-access (LgA) SA of high or low cocaine doses on drug intake, extinction, reinstatement, and brain mRNA levels. Methods...
Rationale. Although the great majority of tobacco addiction begins during adolescence, little is known about differential nicotine effects in adolescents versus adults. Objectives. A rat model was used to determine the impact of the age of onset on nicotine self-administration. Methods. In expt1, nicotine self-administration of female Sprague-Dawley rats over a range of acute doses (0.010.08mg/kg...
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