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The electrophysiological actions of the putative anticonvulsants remacemide hydrochloride and its des-glycine metabolite ARL 12495AA were examined using whole-cell recordings from CA1 hippocampal neurons in adult rat brain in vitro. Remacemide hydrochloride (4-400 μM) and ARL 12495AA (4-400 μM) limited sustained high frequency repetitive firing (SRF) induced by application of long duration depolarizing...
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