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Hemochromatosis is the clinical expression of iron overload and occurs as hereditary and secondary variants. In hereditary hemochromatosis, an inborn error in iron metabolism results in excess absorption of dietary iron, which gradually accumulates in the liver, pancreas, and heart. The most common form of hereditary hemochromatosis is related to homozygosity for the C282Y mutation in the HFE gene...
L'hemochromatose est l'expression clinique d'une surcharge en fer ; elle peut etre genetique ou secondaire. L'hemochromatose genetique resulte d'une erreur innee du metabolisme du fer, responsable d'une hyperabsorption intestinale de fer, a l'origine d'une surcharge progressive des cellules parenchymateuses du foie, du pancreas et du coeur. La forme la plus frequente de la maladie est due a l'homozygotie...
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