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In the recent years, a tremendous body of studies has addressed a broad variety of distinct topics in clinical allergy and immunology. In this update, we discuss selected recent data that provide clinically and pathogenetically relevant insights or identify potential novel targets and strategies for therapy. The role of the microbiome in shaping allergic immune responses and molecular, as well as...
Summary: The innate immune system consists of multiple cell types that express germline‐encoded pattern recognition receptors that recognize pathogen‐associated molecular patterns (PAMPs) or danger‐associated molecular patterns (DAMPs). Allergens are frequently found in forms and mixtures that contain PAMPs and DAMPs. The innate immune system is interposed between the external environment and the...
To cite this article: Tesse R, Pandey RC, Kabesch M. Genetic variations in toll‐like receptor pathway genes influence asthma and atopy. Allergy 2011; 66: 307–316.
AbstractInnate immunity is a pivotal defence system of higher organisms. Based on a limited number of receptors, it is capable of recognizing pathogens and to initiate immune responses. Major components of these innate immunity pathogen...
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