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Adenosine receptors modulate neuronal and synaptic function in a range of ways that may make them relevant to the occurrence, development and treatment of brain ischemic damage and degenerative disorders. A1 adenosine receptors tend to suppress neural activity by a predominantly presynaptic action, while A2A adenosine receptors are more likely to promote transmitter release and postsynaptic depolarization...
Objective To test if mitochondrial (mt)DNA deletions accumulate in brains of patients with multiple sclerosis (MS). Background Previous studies demonstrated an accumulation of oxidative damage to mtDNA and decreased activity of mitochondrial enzymes in lesions of MS, where activated immune cells produce increased amounts of reactive oxygen species and nitric oxide. The unknown link between...
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