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Schizophrenia is a developmental disorder which likely comprises a heterogeneous collection of pathophysiologies converging upon a common end-stage. For example, prenatal exposure to maternal infection increases schizophrenia risk; preclinical studies suggest risk elevation is mediated through the maternal inflammatory response to infection. Prenatal immune activation therefore provides an opportunity...
Patients with schizophrenia have a lifespan that is more than 20 years less than that of the general population. It has been suggested that treatment with antipsychotics is a reason for their reduced lifespan, but patients with schizophrenia are also known to have a more sedentary and unhealthy lifestyle, including heavy smoking, inactivity and obesity. Some antipsychotic medications increase the...
Obsessive-compulsive features are common in schizophrenia. The term schizo-obsessive has been proposed to delineate this subgroup of schizophrenia patients who also present OCS/OCD. Research into clinical, neuropsychological and functional profiles of schizo-obsessive patients has been extensive during these last years although a specific profile has yet to emerge. In addition, the neurobiological...
Numerous lines of evidence converge to suggest that while dopamine-2 receptor antagonism may be necessary for effective schizophrenia treatment, it is as yet insufficient. Network theory indicates that a number of subtle alterations to biological systems are required to change their output effectively: many candidates for such alteration have arisen through preclinical science. Glutamate modulation...
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