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Our understanding of tumor biology has evolved from the consideration of only tumor cell autonomous changes to the realization of the plethora of interactions among various cells and molecules present within the locale of a growing tumor. Characterizing this so-called “tumor microenvironment” has opened a new window of opportunity for both diagnostic and therapeutic approaches. From a therapeutic...
Background Adipose-derived MSC (AMSCs) possess angiogenic and immunomodulatory properties that may modulate kidney regeneration. Whether these properties are retained in older patients with atherosclerotic vascular disease is poorly understood. Hypoxic conditions are known to modify properties and growth characteristics of AMSCs. We tested the hypothesis that AMSCs from older patients with atherosclerotic...
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