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The endothelium, the monolayer covering the inner surface of blood vessels, plays a pivotal role in the regulation of vascular tone and structure, as well as vascular inflammation and thrombosis, i.e., of key events of the atherosclerotic disease process and its clinical complications, such as myocardial infarction and stroke. In particular a reduced endothelial availability of nitric oxide (NO),...
Das Endothel als innere Auskleidung aller Blutgefäße hat eine zentrale Bedeutung in der Homöostase der Gefäßwand. Es stellt ein wichtiges Organ mit autokrinen und parakrinen Eigenschaften dar, das den Gefäßtonus reguliert und entscheidenden Einfluß auf die zelluläre Zusammensetzung der Gefäße ausübt. Durch seine strategische Lage zwischen vorbeiströmendem Blut und Gefäßwand interagiert das Endothel...
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