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Rationale There are many psychotropic drugs available for treatment of schizophrenia. The clinician’s choice of the most effective first-line antipsychotic treatment for patients with schizophrenia should balance considerations of differential efficacy of antipsychotics against the relative risk of different side effects. Method We reviewed recent studies using meta-analytic techniques and additional...
Rationale. While it is generally believed that administration of the dopamine precursor levodopa (l-dopa) exacerbates symptoms of schizophrenia, numerous reports suggest that adjunctive l-dopa may be beneficial. This body of literature has not been critically reviewed. Objectives. On the basis of published studies, to determine whether l-dopa administered concomitantly with antipsychotic drugs provides...
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