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Hydrogen bonding between nucleobases is a crucial noncovalent interaction for the life on Earth. Apart from Watson‐Crick binding, Hoogsteen pairing has been found in many structures of nucleic acids. Methylation of nucleic acids (NAs) is a post‐replication or post‐transcription mechanism that can modulate the structure and function of a NA without changing its sequence. Methylation of adenine at the...
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