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Abstract
Morphine diminishes pain, but its long‐term use is compromised by tolerance and hyperalgesia. Studies implicate δ receptors, β‐arrestin2 and Src kinase in tolerance. We examined whether these proteins are also involved in morphine‐induced hypersensitivity (MIH). A common pathway for tolerance and hypersensitivity may provide a single target to guide improved analgesic approaches. We examined...
Opioid Use Disorder (OUD) and opioid‐related deaths remain a major public health concern in the United States. Both environmental and genetic factors influence risk for OUD. We previously identified Hnrnph1 as a quantitative trait gene underlying the stimulant, rewarding, and reinforcing properties of methamphetamine. Prior work shows that hnRNP H1, the RNA‐binding protein encoded by Hnrnph1, post‐transcriptionally...
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