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Epithelial to mesenchymal transition (EMT), invasion, and motility are essential steps in colorectal cancer (CRC) metastasis regulated by HIF‐1α and NF‐κB. Since HSP90 activates HIF‐1α and NF‐κB, we hypothesized that inhibition of HSP90 leads to inhibition of HIF‐1α and NF‐κB resulting in inhibition of EMT, invasion, and motility. Treatment of colorectal cancer cell lines HT‐29 and HCT‐116 with ganetespib...
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