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Folate and its synthetic form, folic acid, play an important role in one-carbon transfer reactions involved in DNA synthesis and methylation, aberrations of which contribute to the development of colorectal cancer. Indeed, a portfolio of epidemiologic evidence suggests an inverse association between folate status and colorectal cancer risk. However, animal studies and clinical trials collectively...
Background DNA methylation varies throughout the normal colorectal mucosa and DNA methylation in normal appearing mucosa is associated with serrated and adenomatous neoplasia elsewhere within the colorectum. Aims The purpose of this study was to measure luminal chemistry, rectal proliferation and mucosal DNA methylation and thus determine whether regional and pathological patterns of DNA methylation...
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