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The suppression of oestrogen receptor α (ERα) functions by silencing RNAs in association with or not with anti-oestrogens (AEs) both in vitro and in breast cancer cell xenografts was assessed. In vitro, a prolonged decrease in ERα protein expression and an enhanced AE-induced inhibition of ERα-mediated transcription, together with antiproliferative activity, were observed. Incorporation of ERα-siRNAs...
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