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Pancreatic β-cells are poised to sense glucose and other nutrient secretagogues to regulate insulin exocytosis, thereby maintaining glucose homeostasis. This process requires translation of metabolic substrates into intracellular messengers recognized by the exocytotic machinery. Central to this metabolism-secretion coupling, mitochondria integrate and generate metabolic signals, thereby connecting...
Pancreatic β-cells are able to sense glucose and other nutrient secretagogues to regulate insulin exocytosis, thereby maintaining glucose homoeostasis. This systems biology of insulin secretion controls translation of metabolic signals into intracellular messengers recognized by the exocytotic machinery. Central to this metabolism-secretion coupling, mitochondria integrate and generate metabolic signals,...
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