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Objective Although not a standard approach, adjuvant chemotherapy alone is sometimes used to avoid radiotherapy (RT) for anaplastic gliomas, with RT reserved for salvage. The impact of this approach on salvage RT volume size at progression is unknown. We assessed patterns/predictors of response in anaplastic glioma patients treated with adjuvant chemotherapy alone. Methods Anaplastic glioma patients...
The karyotypes of 18 primary ‘untreated’ gliomas, 6 recurrent gliomas treated with radiotherapy and/or chemotherapy and 2 gliomas before and after treatment are described, based on observations using standard cytogenetic techniques. In comparison to the untreated gliomas there were relatively consistent chromosome differences in the treated gliomas, including (1) deletions ofthe long arm of chromosome...
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