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Purpose. To investigate the pharmacokinetics of polyethylene glycol-coated liposomal doxorubicin (PLD, Caelyx) when given as a single agent and in combination with the taxanes paclitaxel or docetaxel in humans. Methods. The plasma kinetics of PLD were studied in 19 cancer patients treated with PLD every 4weeks combined with either paclitaxel (on a weekly basis in seven and as a single infusion in...
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