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Atherosclerosis is the narrowing of arteries due to the accumulation of macrophages overloaded with lipids resulting in foam cell formation, and these events occur preferentially at the branching points of arteries which are particularly susceptible to hyperlipidemic stress-induced inflammation and oxidative stress. The different stages of atherogenesis rely on oxidative stress, endothelial dysfunction,...
Cardiovascular disease remains the leading cause of morbidity and mortality in chronic kidney disease (CKD), and there is an urgent need to develop novel therapeutic strategies to reduce this excessive risk. In the context of uremia, this has been problematic, as the extremely high cardiovascular disease (CVD) risk seems to be the result of a complex interplay between a vast number of traditional,...
Background Endothelial dysfunction is implicated in the initiation and progression of atherosclerosis. Whether atorvastatin combined with rosiglitazone has synergistic effects on endothelial function improvement in the setting of dyslipidemia is unknown. Methods Dyslipidemia rat model was produced with high-fat and high-cholesterol diet administration. Thereafter, atorvastatin, rosiglitazone or...
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