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Pneumococcal disease is a major cause of illness and death in the young, the elderly, and those with certain medical conditions. Pneumococcal conjugate vaccines are changing both the epidemiology of pneumococcal disease and disease burden. Conjugate vaccines were first licensed in 2000 for use in young children; second generation conjugates covering more serotypes became available in 2009 and are...
HIV infection is one of the strongest risk factors for anal squamous cell cancer (ASCC). Most ASCC are caused by HPV, and most HPV-associated ASCC are caused by HPV-16. Anal HPV infections are very common in men who have sex with men (MSM), and nearly universal among HIV-infected MSM. High-grade anal intraepithelial neoplasia (HGAIN), the precursor for ASCC, is present in about 30 % of HIV+ MSM, but...
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