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A series of experiments were conducted to investigate the role of dopaminergic D 1 and D 2 and glutamatergic NMDA and AMPA/kainate receptors on the establishment and expression of cocaine-induced conditioned locomotion in rats. In the first experiment conditioned locomotion was demonstrated by testing the animals in an environment previously associated with 15 mg/kg i.p. cocaine. The...
A balanced conditioning place preference (CPP) paradigm was used to study the role of dopamine D 1 and D 2 and glutamatergic NMDA and AMPA/kainate receptors on the acquisition and expression of cocaine place conditioning.The D 1 receptor antagonist SCH 23390 (0.1–0.2 mg/kg i.p.), administered before cocaine during the training phase, significantly blocked the establishment...
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