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Palmitic acid, or hexadecanoic acid, a 16-carbon saturated fatty acid (FA), accounts for approximately 38% of the total circulating FA in lean or obese humans. In an article published in BMC Medicine, Hall et al. report that cultured islets from healthy donors, when exposed to palmitate, undergo changes in CpG methylation that are associated with modifications of expression in 290 genes. Their results...
Obesity in the United States and other countries throughout the world represents a major health problem. The heritability of obesity susceptibility genes and interaction with components in the “obesogenic environment” promote positive energy balance responsible for weight gain. The molecular basis for gene-environment interactions remains undefined but evidence suggests that obesity susceptibility...
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