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. Regular use of aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) has been associated with decreased incidence of cancer of the colon and other gastrointestinal organs. The chemopreventive properties of NSAIDs are due to their ability to induce apoptosis. Both COX-2-dependent and COX-2-independent mechanisms are involved in NSAIDs-induced neoplastic growth. This article reviews the...
The present study was conducted to explore the potential role of proteasome pathway in NSAIDs-induced apoptosis. We employed sulindac as a NSAID, and chose the lactacystin for inhibition of proteasome activity. Assessment of apoptosis and proteasome activity assay were undertaken. We demonstrated that sulindac treatment resulted in a decrease of proteasome activity, and that the co-treatment of a...
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