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Studies describing subthalamic (STN) local field potentials (LFPs) recorded during deep brain stimulation (DBS) in patients with Parkinson's disease (PD), within the first month after DBS electrode implant, show that DBS modulates specific STN oscillations: whereas low-frequency (LF) oscillations (2–7Hz) increase, beta oscillations (8–30Hz) variably decrease. No data show whether LFPs remain stable...
Excessive synchronization of basal ganglia neuronal activity at ~20Hz is characteristic of patients with untreated Parkinson's disease (PD). Correlative evidence suggests that this activity may contribute to bradykinesia. Attempts to demonstrate causality through stimulation imposed synchronization at 20Hz in the region of the subthalamic nucleus (STN) have had limited success. Finger-tapping is slowed...
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