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Purpose.. To study the combination of 5FUDR, recombinant leukocyte interferon (IFN), and doxorubicin in patients with unresectable hepatocellular carcinoma. Methods.. IFN was administered at a dose of 6 miu/m2 subcutaneously followed in 2h by doxorubicin 20mg/m2 intravenously. After doxorubicin, 5FUDR was given as a 24-h infusion at a starting dose of 80mg/kg. The dose of IFN was escalated to three...
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