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Diabetic nephropathy (DN) is the leading cause of chronic kidney disease and end-stage renal disease (ESRD). Patients with diabetic nephropathy have a high burden of cardiovascular morbidity and mortality. Therefore, interventions that reduce the incidence and progression rate of DN will reduce morbidity and mortality rates as well as health care costs. Hyperglycemia and arterial hypertension are...
The burden of chronic kidney disease represents a major health problem. Experimental studies and evidence in humans suggest that renal damage progresses independently of the initial cause and follows pathogenic mechanisms that are common among different nephropathies. After an initial renal injury, the number of functioning nephrons declines and remaining ones undergo hypertrophy, with concomitant...
Stroke is a devastating co-morbidity in chronic kidney disease that is several -fold more common than in the general population. Although traditional cardiovascular risk factors account for much of the stroke risk in CKD, some risk factors like anemia and dyslipidemia are challenging to address in view of recent clinical trial data that do not seem to provide the full degree of expected benefit from...
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