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Manganese (Mn 2+ )-enhanced magnetic resonance imaging (MEMRI) offers the possibility to generate longitudinal maps of brain activity in unrestrained and behaving animals. However, Mn 2+ is a metabolic toxin and a competitive inhibitor for Ca 2+ , and therefore, a yet unsolved question in MEMRI studies is whether the concentrations of metal ion used may alter brain physiology...
Survival and integration into the host brain of grafted tissue are crucial factors in neurotransplantation approaches. The present study explored the feasibility of using a clinical MR scanner to study striatal graft development in a rat model of Huntington's disease. Rat fetal lateral ganglionic eminences grown as free-floating roller-tube cultures were grafted into the quinolinic acid-lesioned striatum,...
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