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Angiogenin is a powerful stimulator of new blood vessel formation. It is a member of pancreatic ribonuclease (RNase) superfamily. It was originally isolated from conditioned medium of cultured tumor cells. Along with other associated molecules, it has been recognized in a variety of somatic tissues in embryonic stages and adult of vertebrate development. It binds to high-affinity endothelial cell...
Targeted therapies in combination with traditional cytotoxic chemotherapy have revolutionized the treatment of many gastrointestinal malignancies. Although well tolerated in general, they are also associated with unique toxicities and perioperative issues. Anti-vascular endothelial growth factor (VEGF) therapy is the best studied and most widely used targeted strategy in the treatment of GI maligancies...
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