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In this study, we attempted to demonstrate the possibility of rescuing beta-cell exhaustion by chronic intervention with an ATP-sensitive K + channel opener, diazoxide, which reduces the stress of insulin secretion, using rats with streptozotocin-induced diabetes. Three groups of male Wistar rats: (i) controls (n=7), (ii) streptozotocin (30 mg/kg i.v.)-induced diabetic rats (n=10), and (iii)...
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