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Near total striatal dopamine denervation results in a decrease in substance P and an increase in enkephalin messenger RNA expression in the striatum. It is unknown whether partial depletions of striatal dopamine content produce similar changes in these peptide messenger RNAs. To test whether compensations in dopamine synthesis and release following partial dopamine denervation prevent the lesion-induced...
An increase of dynorphin levels is commonly observed in the substantia nigra of 6-hydroxy-dopamine-lesioned rats chronically treated with daily injections ofl-DOPA. This study investigates the potential of fetal mesencephalic grafts to restore normal levels of dynorphin in such cases. After 19 consecutive days of treatment withl-DOPA, lesioned rats with the most severe nigral cell loss showed increased...
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