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An increase of dynorphin levels is commonly observed in the substantia nigra of 6-hydroxy-dopamine-lesioned rats chronically treated with daily injections ofl-DOPA. This study investigates the potential of fetal mesencephalic grafts to restore normal levels of dynorphin in such cases. After 19 consecutive days of treatment withl-DOPA, lesioned rats with the most severe nigral cell loss showed increased...
Recently, both glucocorticoid receptor immunoreactivity and glucocorticoid receptor messenger RNA levels were found in multiple brain areas, especially in the neuroepithelium during the late prenatal development of the rat brain. To better understand the potential influence of stress on fetal brain development by release of maternal adrenocortical steroids, we have investigated the effects of corticosterone...
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